20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the cerebral and renal vasculature. In rat cerebral microvessels, this compound is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. It is excreted mainly as the glucuronide conjugate where the concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide. 20-HETE can be further metabolized by cyclooxygenase to 20-hydroxy PGG2 and 20-hydroxy PGH2.
Soluble in ethanol, DMSO, DMF, PBS (pH 7.2) (≥ 0.8 mg/ml), and 0.1 M Na2CO3 (2 mg/ml).
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Safety & Transport Information
Risk Codes:
R11 - Highly flammable R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S16 - Keep away from sources of ignition - No smoking S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36 - Wear suitable protective clothing
Hazard Symbols:
F, Xi
Storage temperature :
-20°C
RID/ADR certification :
UN 1170 3 / PG 2
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Alternative Distributors of [20-HETE]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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