5(S)-HETE

Element: hete

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C-S » Chemicals » hete-PX78301

Identification

5(S)-HETE

CAS:

70608-72-9

EINECS:

Molecular Formula:

C₂₀H₃₂ O₃

MDL:

MFCD00065820

SMILES:

CCCCC/C=CC/C=CC/C=CC=C[C@H](CCCC(=O)O)O

Synonym:

5-hydroxy-6,8,11,14-eicosatetraenoicacid ; 5(s)-hete lipid maps ms standard ; 5-hete ; 5(s)-hete ; 5-hydroxyeicosatetraenoic acid ; 5-hydroxyeicosatetraenoicacid ; (5s,6e,8z,11z,14z)-5-hydroxy-6,8,11,14-eicosatetraenoicacid ; 5(s)-hydroxyeicosatetraenoic acid ; 6,8,11,14-eicosatetraenoicacid, 5-hydroxy-, (5s,6e,8z,11z,14z)- ; 5s-hydroxy-6,8,11,14-(e,z,z,z)-eicosatetraenoic acid ; 5(s)-hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid ; c04805 ; 5-l-hydroxy-6,8,11,14-eicosatetraenoicacid ; (+)-5-hete, 5(s)-hete ; 6,8,11,14-eicosatetraenoicacid, 5-hydroxy-, [s-(e,z,z,z)]- ; 5-hydroxyicosatetraenoic acid ; (+)-5-hete ; 5-hydroxyeicosatetraenoate

Description

5(S)-HETE is a product of the arachidonic acid metabolism lipoxygenase pathway. It is chemotactic and chemokinetic for human neutrophils, the most abundant white blood cells of the mammalian immune system. It has been shown to elevate cytosolic Ca²⁺, inducing protein kinase C mobilization and thus influencing neutrophil function. It has been observed to stimulate the release of lysozymes from polymorphonuclear leukocytes. It has also been observed to stimulate the release of beta-N-acetylglucosaminidase from polymorphonuclear leukocytes.