12(S),20-DiHETE | CAS 89614-44-8

Element: dihete

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C-S » Chemicals » dihete-PX81452

Identification

12(S),20-DiHETE

CAS:

89614-44-8

EINECS:

Molecular Formula:

C₂₀H₃₂ O₄

MDL:

SMILES:

C(CCC=CC[C@@H](C=CC=CCC=CCCCC(=O)O)O)CCO

Synonym:

12(s),20-dihydroxyeicosa-5(z),8(z),10(e),14(z)-tetraenoicacid ; 12,20-dihete ; (5z,8z,10e,12s,14z)-12,20-dihydroxy-5,8,10,14-eicosatetraenoic acid ; 5,8,10,14-eicosatetraenoicacid, 12,20-dihydroxy-, [s-(e,z,z,z)]- ; 12s,20-dihydroxy-5,8,10,14-(z,z,e,z)-eicosatetraenoic acid ; 12(s),20-dihydroxyeicosa-5z,8z,10e,14z-tetraenoic acid ; 5,8,10,14-eicosatetraenoicacid, 12,20-dihydroxy-, (5z,8z,10e,12s,14z)- ; 12(s),20-dihete

Description

12(S),20-DiHETE, an arachidonic acid metabolite, has been demonstrated to be formed from 12-hydroxyeicosatetraenoic acid (12-HETE) during interaction between platelets and unstimulated neutrophils. This formation has been shown to be blocked by cytochrome P-450 inhibitors and leukotriene B4. Studies suggest that 12(S),20-DiHETE activates both cytoplasmic and lysosomal cholesteryl ester hydrolytic activity.