5(S),6(R)-DiHETE | CAS 82948-88-7

Element: dihete

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C-S » Chemicals » dihete-PX72934

Identification

5(S),6(R)-DiHETE

CAS:

82948-88-7

EINECS:

Molecular Formula:

C₂₀H₃₂O₄

MDL:

SMILES:

CCCCC/C=CC/C=CC=CC=C[C@@H](O)[C@@H](O)CCCC(=O)O

Synonym:

5s,6r-dihydroxy-7e,9e,11z,14z-eicosatetraenoic acid ; 5(s),6(r)-dihete ; 5(s),6(r)-dihete lipid maps ms standard ; [5s,6s]-dihete ; (5s,6s)-dihydroxy-(7e,9e,11z,14z)-eicosatetraenoic acid ; 5(s),6(r)-dihydroxyeicosa-7e,9e,11z,14z-tetraenoic acid

Description

5(S),6(R)-DiHETE is an enzymatic metabolite of leukotriene A4 that functions as a CysLT1 Receptor (LTD4 receptor) agonist. Studies show that the activation of the CysLT1 Receptor results in the contraction of lung parenchyma cells. In addition, it is the vicinal diol's specific structure that is essential for binding to the CysLT1 Receptor since other stereoisomers of the agonist do not bind to the receptor. These contractions in lung parenchyma cells are readily inhibited by FPL 55712.

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Santa Cruz Biotechnology, Inc.

200421

Santa Cruz Biotechnology, Inc.

sc-200421

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Prices & Availability

Data is processed

Properties for 5(S),6(R)-DiHETE

Molecular Weight:

336.47 g·mol−1

Boiling point:

78° C

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

F, Xi