8(S),15(S)-DiHETE (Z, E, Z, E) | CAS 80234-65-7

Element: dihete

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Identification

8(S),15(S)-DiHETE (Z, E, Z, E)

CAS:

80234-65-7

EINECS:

Molecular Formula:

C₂₀H₃₂O₄

MDL:

SMILES:

CCCCC[C@@H](/C=C/C=CC=C[C@H](C/C=CCCCC(=O)O)O)O

Synonym:

(8s,15s)-dihete ; 8(s),15(s)-dihydroxyeicosa-5z,9e,11z,13e-tetraenoic acid ; (8s,15s)-dihydroxy-(5z,9e,11z,13e)-eicos atetraenoi ; 8(s),15(s)-dihete (z, e, z, e) ; (8s,15s)-dihydroxy-(5z,9e,11z,13e)-eicosatetraenoic acid ; (8s,15s)-dihydroxy-(5z,9e,11z,13e)-*eicosatetraen

Description

8(S),15(S)-DiHETE (Z, E, Z, E) is a novel dioxygenation product of arachidonic acid which possesses chemotactic activity for human polymorphonuclear leukocytes (PMNLs) comparable to that of leukotriene B4. Studies show that (8S,15S)-diHETE from PMNLs, keratinocytes, and other epithelial cells may modulate normal primary afferent function and contribute to inflammatory hyperalgesia. Studies show that 8(S)-15(S)-diHETE antagonizes the hyperalgesic activity of its stereoisomer 8(R)-15(S)-diHETE but does not suppress PGE-2 induced hyperalgesia.

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Santa Cruz Biotechnology, Inc.

200415

Santa Cruz Biotechnology, Inc.

sc-200415

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Prices & Availability

Data is processed

Properties for 8(S),15(S)-DiHETE (Z, E, Z, E)

Molecular Weight:

336.47 g·mol−1

Boiling point:

78° C

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

F, Xi