N-Desmethyl Sildenafil | CAS 139755-82-1

Element: sildenafil desmethyl

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C-S » Chemicals » desmethyl-sildenafil-PX73290

Identification

N-Desmethyl Sildenafil

CAS:

EINECS:

Molecular Formula:

MDL:

SMILES:

CCCC1=NN(C)C2=C1N=C(NC2=O)C1=CC(=CC=C1OCC)S(=O)(=O)N1CCNCC1

Synonym:

Description

N-Desmethyl Sildenafil is a metabolite of Sildenafil. Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.