N-Desmethyl Sildenafil-d8 | CAS 1185168-06-2

Element: sildenafil desmethyl

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C-S » Chemicals » desmethyl-sildenafil-PX61341

Identification

N-Desmethyl Sildenafil-d8

CAS:

1185168-06-2

EINECS:

Molecular Formula:

C₂₁H₂₀D₈N₆O₄S

MDL:

SMILES:

[2H]C1(C(N(C(C(N1)([2H])[2H])([2H])[2H])S(=O)(=O)C2=CC(=C(C=C2)OCC)C3=NC(=O)C4=C(N3)C(=NN4C)CCC)([2H])[2H])[2H]

Synonym:

Description

N-Desmethyl Sildenafil-d8 is a deuterium-labelled analog of Sildenafil. Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.

Suppliers

Santa Cruz Biotechnology, Inc.

219131

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CAS equal suppliers

N-Desmethyl sildenafil d8

Santa Cruz Biotechnology, Inc.

SCB22509000

N-desmethyl Sildenafil D8

BOC Sciences

BS9002700

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Properties for N-Desmethyl Sildenafil-d8

Molecular Weight:

468.60 g·mol−1

Melting point:

156-158°C (lit.)

Solubility:

Chloroform, DMSO

Safety & Transport Information

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Alternative Distributors of [N-Desmethyl Sildenafil-d8]

Producers or manufacturers change the product range from time to time. The following companies
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Clearsynth Canada INC.