Bafilomycin A1 | CAS 88899-55-2 | Chemical-Suppliers

Element: bafilomycin

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C-S » Chemicals » bafilomycin-PX81890

Identification

Bafilomycin A1

CAS:

88899-55-2

EINECS:

Molecular Formula:

C₃₅H₅₈ O₉

MDL:

MFCD06795130

SMILES:

C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C

Synonym:

bafilomycin a1, 98+% ; oxacyclohexadeca-3,5,11,13-tetraen-2-one,8-hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2h-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-,[7r-[3z,5e,7r*,8s*,9s*,11e,13e,15s*,16r*[1s*,2r*,3s*(2r*,4r*,5s*,6r*)]]]- ; bafilomycin a1 95% ; nsc381866 ; oxacyclohexadecane, hygrolidin deriv. ; bafilomycin a1,95% ; bafilomycina1fromstreptomycesgriseus ; (3z,5e,7r,8s,9s,11e,13e,15s,16r)-8-hydroxy-16-((1s,2r,3s)-2-hydroxy-1-methyl-3-((2r,4r,5s,6r)-tetrahydro-2,4-dihydroxy-5 ; bafilomycin a1 bafilomycin a1 from streptomyces griseus ; oxacyclohexadeca-3,5,11,13-tetraen-2-one,8-hydroxy-16-[(1s,2r,3s)-2-hydroxy-1-methyl-3-[(2r,4r,5s,6r)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2h-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-,(3z,5e,7r,8s,9s,11e,13e,15s,16r)- ; 21-o-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin ; bafilomycin a1 ; bafilomycin a1, streptomyces griseus ; bafilomycin a1 from streptomycesgriseus, 10 ug ; hygrolidin,21-o-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl- ; (-)-bafilomycin a1

Description

Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type H⁺ ATPase) and belongs to a class of membrane ATPase inhibitors. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.

Suppliers

Aea.ltd

A196392

Chemlyte Solutions

CS5041512

Indofine Chemical Co, Inc.

Bio-049

Alpha Biopharmaceuticals Co., Ltd.

AB9522856

Alfa (A Johnson Matthey Company)

A8962688

Iris Biotech GmbH

LS-1081.0000

Xingrui Industry Co., Limited

XIL8123248

BOC Sciences

BS3361008

Leap Chem Co., Ltd

LC5041512

Santa Cruz Biotechnology, Inc.

201550

Dayang Chem (Hangzhou) Co.,Ltd.

DC8683472

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CAS equal suppliers

Bafilomycin A1, 95%

Iris Biotech GmbH

LS-1081

Bafilomycin A1, 0.1mg/mL in DMSO, sterile-filtered

Alfa (A Johnson Matthey Company)

A1120033600

Prices & Availability

Data is processed

Properties for Bafilomycin A1

Molecular Weight:

622.8296 g·mol−1

Density:

1.12 g/cm3

Boiling point:

770.1 °C at 760 mmHg

Flash point:

232.2 °C

Solubility:

Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water.

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Classes:

6.1(b)

Hazard Symbols:

Storage temperature :

2-8°C

RID/ADR certification :

3172

Alternative Distributors of [Bafilomycin A1]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Jinan Great Chemical Co., Ltd. | Fermentek Ltd.

Downloads

Mol File:

-/-

MSDS:

-/-

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Bafilomycin A1, from Streptomyces griseus

Bafilomycin A1, 0.1mg/mL in DMSO, sterile-filtered