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Valproic acid sodium salt

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Formula: C8H15NaO2
CAS: 1069-66-5
search Element: valproic sodium acid salt
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Identification

Structural Formula
Valproic acid sodium salt
CAS:
1069-66-5
EINECS:
213-961-8
Molecular Formula:
C8H15NaO2
MDL:
MFCD00078604
SMILES:
CCCC(CCC)C(=O)[O-].[Na+]
Synonym:
valerin ; leptilan ; depacon ; kw6066n ; depakin ; orfiril ; valdisoval ; eurekene ; acediprol ; labazene


Description

Valproic Acid, Sodium Salt is a branched chain fatty acid which is reported to inhance central GABAergic neurotransmission and inhibit Sodium Channel Protein (Na+ channels). This compound is also reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. Valproic Acid has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 μM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase. This compound is also an inhibitor of the CYP2C9 enzyme.


Suppliers

Xingrui Industry Co., Limited
XIL290011600
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Santa Cruz Biotechnology, Inc.
202378
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Prices & Availability




Data is processed


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Properties for Valproic acid sodium salt

Molecular Weight:
166.19 g·mol−1
Melting point:
300 °C
Solubility:
H2O: 50 mg/mL
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R36/38 - Irritating to eyes and skin
R61 - May cause harm to the unborn child
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Classes:
6.1(b)
Hazard Symbols:
Xn, T, Xi
Hazard symbol T Hazard symbol Xn Hazard symbol Xi
Storage temperature :
Desiccate at RT
RID/ADR certification :
2811
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Alternative Distributors of [Valproic acid sodium salt]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Suzhou Rovathin Pharmatech Co., Ltd | Jinan Haohua Industry Co., Ltd.

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