rac 5-Hydroxy Valproic Acid Sodium Salt

rac 5-Hydroxy Valproic Acid Sodium Salt is a racemic mixture of 5-Hydroxy Valproic Acid, a metabolite of Valproic Acid. In the metabolism of Valproic Acid to 5-Hydroxy Valproic Acid, it has been reported that CYP4B1 may play a role in this conversion, as demonstrated using monospecific polyclonal antibodies directed against CYP4B1. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na⁺ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase.