Tyrphostin AG 1295 | CAS 71897-07-9

Element: tyrphostin 1295

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Identification

Tyrphostin AG 1295

CAS:

71897-07-9

EINECS:

Molecular Formula:

C₁₆H₁₄N₂

MDL:

MFCD00270912

SMILES:

CC1=CC2=NC=C(N=C2C=C1C)C3=CC=CC=C3

Synonym:

6,7-dimethyl-2-phenyl-quinoxaline

Description

Tyrphostin AG 1295 is a selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC₅₀ = 500 nM) and PDGF-dependent DNA synthesis (IC₅₀ = 2.5 μM) in Swiss/3T3 cells, and demonstrates about 50% inhibition on neointimal formation after balloon injury in porcine femoral arteries. Tyrphostin AG 1295 has been shown to selectively attenuate smooth muscle cell growth in vitro, and to reduce the autophosphorylation of PDGF receptor (R), thereby supressing the enhancement by PDGF-BB without affecting the FGF-2 effect.