Tyrphostin AG 99 | CAS 118409-59-9

Element: tyrphostin

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » tyrphostin-PX68413

Identification

Tyrphostin AG 99

CAS:

118409-59-9

EINECS:

Molecular Formula:

C₁₀H₈N₂O₃

MDL:

MFCD00133901

SMILES:

C1=CC(=C(C=C1C=C(C#N)C(=O)N)O)O

Synonym:

3,4-dihydroxy-α-cyanocinnamamide ; nsc666250 ; 2-propenamide,2-cyano-3-(3,4-dihydroxyphenyl)- ; ag 99 ; nsc 638077 ; nsc 666250 ; tyrphostin 46 ; tyrphostin b40 ; aids-085248 ; tyrphostin a 46 ; tyrphostin a46 ; aids085248 ; tyrphostin 11 ; tyrphostin ag 99 ; ag 99 (tyrphostin a46)

Description

Tyrphostin AG 99 is a potent, cell-permeable, reversible inhibitor of EGFR (epidermal growth factor receptor) and EGF-dependent cell proliferation. Stimulation of EGFRs result in tumor growth and proliferation, inhibition of apoptosis, stimulation of angiogenesis and the promotion of tissue invasion and metastasis. Tyrphostin AG 99 has been shown to inhibit EGFR phosphorylation and ERK1 and ERK2 activities.