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Tyrphostin AG 957

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Formula: C15H15NO4
CAS: 140674-76-6
search Element: tyrphostin
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Identification

Structural Formula
Tyrphostin AG 957
CAS:
140674-76-6
EINECS:
Molecular Formula:
C15H15NO4
MDL:
MFCD01074970
SMILES:
COC(=O)C1=CC=C(C=C1)NCC2=C(C=CC(=C2)O)O
Synonym:


Description

Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210bcr-abl (Ki = 750 nM) over p140c-abl (Ki = 10 μM). Also decreases p210bcr-abl phosphorylation in viable K562 cells at concentrations and durations of exposure that also inhibit cell proliferation. Reported to alter the physical state of p210bcr-abl and the association of p210bcr-abl with Shc and Grb2 in K562 cells.


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Santa Cruz Biotechnology, Inc.
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Properties for Tyrphostin AG 957

Molecular Weight:
273.28 g·mol−1
Density:
1.34 g/cm3 (Predicted)
Melting point:
176.63° C (Predicted)
Boiling point:
504.16° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (5 mg/ml), acetone, and ethyl acetate. Insoluble in dichloromethane.
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Alternative Distributors of [Tyrphostin AG 957]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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