Tyrphostin RG 14620 | CAS 136831-49-7

Element: tyrphostin 14620

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C-S » Chemicals » tyrphostin-PX76163

Identification

Tyrphostin RG 14620

CAS:

136831-49-7

EINECS:

Molecular Formula:

C₁₄H₈ Cl₂ N₂

MDL:

MFCD00236445

SMILES:

C1=CC(=CN=C1)C(=CC2=CC(=CC(=C2)Cl)Cl)C#N

Synonym:

3-Pyridineacetonitrile,a-[(3,5-dichlorophenyl)methylene]-

Description

Tyrphostin RG 14620 is a non-phenolic tyrphostin analog, which is selective for the EGFR (EGF receptor). The compound inhibits EGF-stimulated HER14 cell proliferation (IC₅₀=3 μM) as well as tumor growth in vivo. Tyrphostin RG 14620 contains anti-proliferative effects on renal and bladder carcinoma cell lines. Tyrphostin RG 14620 is an inhibitor of Tyrosine Kinase.