Tyrphostin AG 879 | CAS 148741-30-4

Element: tyrphostin

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C-S » Chemicals » tyrphostin-PX67537

Identification

Tyrphostin AG 879

CAS:

148741-30-4

EINECS:

Molecular Formula:

C₁₈H₂₄N₂OS

MDL:

MFCD00236450

SMILES:

CC(C)(C)C1=CC(=CC(=C(N)S)C#N)C=C(C1=O)C(C)(C)C

Synonym:

(e)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide ; tyrphostin 879 ; alpha-cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide ; (e)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide ; alpha-cyano-(3,5-di-tert-butyl-4-hydroxy)thiocinnamamide ; tyrphostin ag 879 ; (3,5-di-t-butyl-4-hydroxybenzylidene)thiocyanoacetamide ; α-cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide ; 2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide ; ag 879

Description

Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. This product reportedly inhibits NGF-induced PLC-γ 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell aggregation and stop androgen-induced cell proliferation. AG 879 also displays anti-cancer effects by inhibiting the expression of RAF-1 gene encoding MAP kinase activity necessary for human breast cancer cell proliferation. Shown to inhibit Neu (HER-2 or ERBB2) expression and reduced tumor sizes in mice leukemia cells. Tyrphostin AG 879 is an inhibitor of Flk-1.