tyrphostin ag 490 ; (2e)-n-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide ; tyrphostin ag 490
ag 490 ; ag 490, >=98% ; tyrphostin b42 ; tyrphostin ag490 ; zinc02557947 ; ag 490 ; ag-490 (tyrphostin b42) ; 2-propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-n-(phenylmethyl)-, (2e)- ; bis-tyrphostin b42 ; tyrophostin ag490 ; ag 490 (tyrphostin ag 490) ; 2-propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-n-(phenylmethyl)-, (e)-
Description
Tyrphostin B42 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, Tyrphostin B42 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, Tyrphostin B42 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that Tyrphostin B42 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by Tyrphostin B42 leads to lower levels of p85 phosphorylation and p-13 kinase activation.
R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin R50 - Very toxic to aquatic organisms
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36 - Wear suitable protective clothing S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
Hazard Symbols:
Xi, N, T
Storage temperature :
-20°C
x
Alternative Distributors of [Tyrphostin B42]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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