Tyrphostin 47 | CAS 122520-86-9 | Chemical-Suppliers

Element: tyrphostin

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C-S » Chemicals » tyrphostin-PX1490908

Identification

Tyrphostin 47

CAS:

122520-86-9

EINECS:

Molecular Formula:

C₁₀H₈N₂O₂S

MDL:

SMILES:

C1=CC(=O)C(=C/C1=C/C(=C(/N)S)/C#N)O

Synonym:

3,4-dihydroxy-alpha-cyanothiocinnamamide ; tyrphostin a47 99+% ; rg-50864 ; tyrphostin rg 50864 ; ag 213 ; ag 213 (tyrphostin ag 213) ; tyrphostin ag 213 ; alpha-cyano-(3,4-dihydroxy)thiocinnamide ; tyrphostin 47 ; tyrphostin a47

Description

Tyrphostin 47 is a protein tyrosine kinase inhibitor particularly potent against epidermal growth factor receptor (EGFR) kinase activity. Tyrphostin 47 has been observed to inhibit GTPase activity of transducin and the homologous insulin receptor kinase. It has also been found to also inhibit hyperactive motility of hamster spermatozoa. Tyrphostin 47 interferes with the proximal EGFR signaling pathway, causes G1-S transition arrest, and induces apoptosis in the human MCF-7 breast cancer cell line. In vero cell cultures, this product induced cell death and p38 MAPK phosphorylation.