Tyrphostin AG 490 | CAS 133550-30-8

Element: tyrphostin

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C-S » Chemicals » tyrphostin-PX1174292

Identification

Tyrphostin AG 490

CAS:

133550-30-8

EINECS:

Molecular Formula:

C₁₇H₁₄N₂O₃

MDL:

MFCD00209833

SMILES:

C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

Synonym:

ag 490 (tyrphostin ag 490) ; ag 490 ; tyrphostin ag490 ; ag-490 (tyrphostin b42) ; tyrophostin ag490 ; tyrphostin ag 490 ag 490 ; bis-tyrphostin b42 ; ag 490, >=98% ; tyrphostin ag 490 ; 2-propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-n-(phenylmethyl)-, (e)- ; (2e)-n-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide ; zinc02557947 ; tyrphostin b42 ; 2-propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-n-(phenylmethyl)-, (2e)-

Description

Tyrphostin AG 490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, Tyrphostin AG 490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, Tyrphostin AG 490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that Tyrphostin AG 490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by Tyrphostin AG 490 leads to lower levels of p85 phosphorylation and p-13 kinase activation.

Suppliers

Leap Chem Co., Ltd

LC6121836

Santa Cruz Biotechnology, Inc.

216033

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CAS equal suppliers

AG 490

BOC Sciences

BS72216

AG 490

Aea.ltd

A4284

AG-490

ShangHai Biochempartner Co., Ltd.

BCP01722

AG-490

Excenen Pharmatech Co., Ltd.

EX-A118

AG-490

Chemieliva Pharmaceutical Co., Ltd.

CP210630

AG-490

Hangzhou J&H Chemical Co., Ltd.

HJC186744

AG-490

Ambeed, Inc.

A205043

AG-490

CSNpharm, Inc.

CSN13724

Tyrphostin B42

Santa Cruz Biotechnology, Inc.

3556

Tyrphostin B42

Dayang Chem (Hangzhou) Co.,Ltd.

DC8683472

Tyrphostin B42

Aea.ltd

A196392

(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC111477

(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide

Capot Chemical Co., Ltd.

34060

(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

Manchester Organics Limited

H38763

Prices & Availability

Data is processed

Properties for Tyrphostin AG 490

Molecular Weight:

294.10 g·mol−1

Density:

1.337 g/cm3

Melting point:

216.5° C

Boiling point:

615.21 °C at 760 mmHg

Flash point:

325.867 °C

Solubility:

ethanol: 5 mg/mL

Physical Description:

yellow solid

Safety & Transport Information

Risk Codes:

R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R50 - Very toxic to aquatic organisms

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Symbols:

Xi, N, T

Storage temperature :

-20°C

Alternative Distributors of [Tyrphostin AG 490]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH