Topotecan | CAS 123948-87-8 | Chemical-Suppliers

Element: topotecan

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C-S » Chemicals » topotecan-PX90583

Identification

Topotecan

CAS:

123948-87-8

EINECS:

Molecular Formula:

C₂₃H₂₃N₃O₅

MDL:

MFCD00870670

SMILES:

CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O

Synonym:

nogitecan ; skf-s 104864 ; topotecan ; hycamptamine ; hycamptin ; muriatic acid ; nsc 609699 ; skf 104864 ; hydrochloride ; skf-104864a

Description

Topotecan is a potent inhibitor of Topo I (topoisomerase I), producing proapoptotic and antiproliferative effects. Topotecan is a semisynthetic derivative of the natural product alkaloid Camptothecin. Topotecan is described to stabilize topoisomerase I/DNA cleavable complexes and promote rapid apoptotic cell death in radiation-resistant human B-lineage acute lymphoblastic leukemia cells.

Suppliers

Chemlyte Solutions

CS162486

Aozeal Certified Standards (AOCS), Inc.

T0113.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

H&Z Industry Co.,Ltd

HIC180720

CSNpharm, Inc.

CSN12922

Hangzhou Keying Chem Co., Ltd.

HKC2701080

scienTEST - bioKEMIX GmbH

S-B225900

Finetech Industry Limited

FIL225900

Carbone Scientific Co., Ltd.

CS252756

Xingrui Industry Co., Limited

XIL2611044

Zehao Industry Co., Ltd.

ZI216648

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

338718

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Prices & Availability

Data is processed

Properties for Topotecan

Molecular Weight:

421.45 g·mol−1

Density:

1.2 g/mL at 25 °C(lit.)

Melting point:

-114 °C(lit.)

Boiling point:

>100 °C(lit.)

Flash point:

12 °C

Solubility:

H₂O: soluble

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R20 - Harmful by inhalation
R34 - Causes burns
R35 - Causes severe burns
R36 - Irritating to eyes
R36/37/38 - Irritating to eyes, respiratory system and skin
R46 - May cause inheritable genetic damage
R48 - Danger of serious damage to health by prolonged exposure
R67 - Vapours may cause drowsiness and dizziness

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S7 - Keep container tightly closed

Hazard Classes:

Hazard Symbols:

T, C, F, Xi
Hazard symbol T

Storage temperature :

2-8°C

RID/ADR certification :

UN 3286 3 / PG 2

Alternative Distributors of [Topotecan]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified