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D-threo-PDMP

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Formula: C23H38N2O3.ClH
CAS: 109836-82-0
search Element: threo pdmp
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Identification

Structural Formula
D-threo-PDMP
CAS:
109836-82-0
EINECS:
Molecular Formula:
C23H38N2O3.ClH
MDL:
SMILES:
CCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@@H](C2=CC=CC=C2)O.Cl
Synonym:
d-threo-pdmp hcl ; d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hcl ; d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride (d-threo-pdmp) ; decanamide,n-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, [r-(r*,r*)]- ; d-threo-1-phenyl-2-(decanoylamino)-3-morpholino-1-propanol ; decanamide,n-[(1r,2r)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-


Description

d-threo-PDMP is an inhibitor of the enzyme UGCG (glycosylceramide synthase) which is the intial step in the glycosylation of ceramide. Studies show that d-threo-PDMP decreases cell surface glycosphingolipids via inhibiting glycosylation. It is believed that d-threo-PDMP can increase the number of ceramide in cells which in directly leads to apoptosis and stops cellular development. Axonal studies show that d-threo-PDMP reduces the total length of the axon plexus and the number of axonal branch points. Studies involving SH-SY5Y cells indicate that d-threo-PDMP can inhibit the outgrowth of neurite.


Suppliers

Indofine Chemical Co, Inc.
56-1170
Santa Cruz Biotechnology, Inc.
280659
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Prices & Availability




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Properties for D-threo-PDMP

Molecular Weight:
427.025 g·mol−1
Solubility:
Soluble in ethanol, methanol
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Safety & Transport Information

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Alternative Distributors of [D-threo-PDMP]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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