Sulindac | CAS 38194-50-2 | Chemical-Suppliers

Element: sulindac

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C-S » Chemicals » sulindac-PX71057

Identification

Sulindac

CAS:

38194-50-2

EINECS:

253-819-2

Molecular Formula:

C₂₀H₁₇FO₃S

MDL:

MFCD00599589

SMILES:

CC1=C(C2=C(/C1=C/C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O

Synonym:

sulreuma ; sulinol ; clisundac ; saldac ; reumyl ; clinoril ; mobilin ; (z)-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid ; mk 231 ; aclin ; 1h-indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1z)- ; mk-231 ; sudac ; imbaral ; artribid ; arthrocine ; 1h-indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (z)- ; aflodac ; reumofil

Description

Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. Sulindac metabolizes to sulindac sulfide, a Cox (cyclooxygenase) inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.

Suppliers

Aozeal Certified Standards (AOCS), Inc.

S0103.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI5522208

H&Z Industry Co.,Ltd

HIC160640

Shandong SanYoung Industry Co., Ltd

SSI2801120

Chemlyte Solutions

CS144432

Hangzhou Cherry Pharmaceutical Technology Co., Ltd.

HCPT4082040

CSNpharm, Inc.

CSN12016

Hangzhou Keying Chem Co., Ltd.

HKC240960

Sigma-Aldrich International GmbH

SI256768

Finetech Industry Limited

FIL200800

CM Fine Chemicals

CFC136544

AK Scientific, Inc.

AS152456

Xingrui Industry Co., Limited

XIL232928

Leap Chem Co., Ltd

LC144432

Santa Cruz Biotechnology, Inc.

202823

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CAS equal suppliers

(1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid

Gihi Chemicals Co., Limited

GCL30186120744

(1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid

BLD Pharmatech Ltd

BP2012460372

Prices & Availability

Data is processed

Properties for Sulindac

Molecular Weight:

356.42 g·mol−1

Density:

1.38 g/cm3

Melting point:

182-185 °C

Boiling point:

581.6 °C at 760 mmHg

Flash point:

305.6 °C

Solubility:

Soluble in water (0.05 mg/ml at 25° C), methanol (50 mg/ml), ethanol (9 mg/ml at 25° C), DMSO (71 mg/ml at 25° C), and DMF (~ 30 mg/ml).

Physical Description:

yellow crystalline solid

Transport Information:

UN 3249

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R42/43 - May cause sensitization by inhalation and skin contact
R63 - Possible risk of harm to the unborn child

Hazard Classes:

6.1(b)

Hazard Symbols:

Storage temperature :

Store at RT

RID/ADR certification :

3249

Alternative Distributors of [Sulindac]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified