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Sulindac sulfide

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Formula: C20H17 F O2 S
CAS: 49627-27-2
search Element: sulindac sulfide
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Identification

Structural Formula
Sulindac sulfide
CAS:
49627-27-2
EINECS:
Molecular Formula:
C20H17 F O2 S
MDL:
SMILES:
CC1=C(C2=C(C1=CC3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O
Synonym:
1h-indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (z)- ; cis-sulindac sulfide ; (z)-5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1h-indene-3-acetic acid ; (z)-sulindac sulfide ; 5-fluoro-2-methyl-1-[(z)-[4-(methylthio)phenyl]methylene]-1h-indene-3-acetic acid ; z-sulindac sulfide ; (z)-5-fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid ; sulindac sulphide ; 1h-indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (z)- ; sulindacsulfide ; 1h-indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1z)- ; (z)-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-1h-inden-3-ylacetic acid ; einecs 256-403-9


Description

Sulindac Sulfide, a metabolite of Sulindac, is a non-steroidal anti-inflammatory compound that demonstrates inhibition of Cox-1(ID50=0.5 μM), Cox-2 (ID50=14 μM), and γ-secretase. This compound has also been shown to be an inhibitor of Ras activation of Raf-1; it impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. Sulindac Sulfide has been shown to inhibit growth and induce apoptosis in human prostate cancer cell cultures through a Cox-1 and Cox-2 independent mechanism. Sulindac Sulfide is an inhibitor of NFκB.


Suppliers

Leap Chem Co., Ltd
LC5761728
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Santa Cruz Biotechnology, Inc.
200118
Dayang Chem (Hangzhou) Co.,Ltd.
DC9923968
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Prices & Availability




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Properties for Sulindac sulfide

Molecular Weight:
340.41 g·mol−1
Density:
1.3 g/cm3
Melting point:
189-191 °C
Boiling point:
526.3°C at 760 mmHg
Flash point:
272.1°C
Solubility:
DMSO: >22 mg/mL
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R42/43 - May cause sensitization by inhalation and skin contact
R63 - Possible risk of harm to the unborn child
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
-20 °C Freezer
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Alternative Distributors of [Sulindac sulfide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Salsbury Chemicals, Inc., | Clearsynth Canada INC.

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MSDS:
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