Prazosin-d8

Prazosin-d8 is a deuterium-labeled analog of Prazosin. Prazosin is an adrenergic α, α_2B-adrenoceptor and a potent melatonin MT3 receptor antagonist. A study investigated the putative inhibitory effect of prazosin on changes evoked by a NMDA receptor antagonist, MK-801 within the Syrian hamster hypothalamus. This study reported that prazosin was a potent and selective α1-adrenoceptor antagonist and was able to supress MK-801 evoked changes, without affecting basal dopamine release in nucleus accumbens. Additionally, in this study prazosin was reported to block MK-801 evoked locomotor stimulation with little affect on basal locomotor activity.