PGH2 (Prostaglandin H2) | CAS 42935-17-1

Element: prostaglandin pgh2

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C-S » Chemicals » pgh-prostaglandin-PX68888

Identification

PGH2 (Prostaglandin H2)

CAS:

42935-17-1

EINECS:

Molecular Formula:

C₂₀H₃₂O₅

MDL:

MFCD00036972

SMILES:

CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=CCCCC(=O)O)OO2)O

Synonym:

[1-14c]prostaglandin?h2 ; prostaglandin h2 ; prostaglandin h2 solution ; pgh2 ; pgh2 (prostaglandin h2) ; prostaglandin?h2?(pgh2) ; endoperoxide h2 ; gpr142 ; pgr2 ; prostaglandin r2

Description

PGH2 (Prostaglandin H2), a precursor for the 2-series thromboxanes and prostaglandins, is a potent platelet aggregator of vascular smooth muscle contraction. PGH2 is also an inhibitor of platelet TXA synthase (thromboxane synthase). In the rabbit pulmonary artery PGH2 activated the stretch induced contraction of rabbit pulmonary artery. At an IC₅₀ at 10-25 ng/ml in the isolated rat fat cell PGH2 inhibited the accumulation of noradrenaline induced cyclic AMP.

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Properties for PGH2 (Prostaglandin H2)

Molecular Weight:

352.47 g·mol−1

Flash point:

-17 °C

Solubility:

Soluble in 9:1 hexane : isopropyl alcohol, ethanol (~100 mg/ml), PBS (pH 7.2) (~2 mg/ml), DMSO, and methanol.

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R36 - Irritating to eyes
R66 - Repeated exposure may cause skin dryness or cracking
R67 - Vapours may cause drowsiness and dizziness

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S9 - Keep container in a well-ventilated place

Hazard Symbols:

F, Xi