PGA1 (Prostaglandin A1) | CAS 14152-28-4

Element: prostaglandin pga1

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C-S » Chemicals » pga-prostaglandin-PX63369

Identification

PGA1 (Prostaglandin A1)

CAS:

14152-28-4

EINECS:

Molecular Formula:

C₂₀H₃₂O₄

MDL:

MFCD00077858

SMILES:

CCCCC[C@H](O)C=C[C@H]1C=CC(=O)[C@@H]1CCCCCCC(O)=O

Synonym:

c04685 ; prostaglandin a1 ; pga1 ; pga(sup1) ; prostaglandins a1 ; prostaglandine(sup1)-217 ; prostaglandina(sup1) ; pga(sub1) ; pga1 (prostaglandin a1) ; prostaglandina(sub1)

Description

PGA1 (Prostaglandin A1) is an anti-inflammatory cyclopentenone prostaglandin, biosynthesized from dihomo-γ-linolenic acid, and was originally discovered as a dehydration product of PGE1. PGA1 has been shown to cause renal vasodilation, stimulate renin release, inhibit NFκB activation, activate PPARs, and induce thermotolerance through modulation of heat shock protein 70. Furthermore this product has been shown to inhibit the proliferation of tumor cells with an IC₅₀ = 7.5 μM for ovarian tumor cell cultures.