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Olomoucine

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Formula: C15H18N6O
CAS: 101622-51-9
search Element: olomoucine
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Identification

Structural Formula
Olomoucine
CAS:
101622-51-9
EINECS:
Molecular Formula:
C15H18N6O
MDL:
MFCD00189360
SMILES:
CN1C=NC2=C1N=C(N=C2NCC3=CC=CC=C3)NCCO
Synonym:
olomoucine synthetic >95% ; 2-(hydroxyethylamino)-6-benzylamino-9-methylpurine ; olomoucine ; olomoucine,98%,high purity ; olomoucine,highpurity ; nsc 666096 ; n2-[(2-hydroxyethyl)]-n6-benzyladenine ; 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine ; 6-benylamino-2-(2-hydroxyethylamino)-9-methylpurine ; 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine


Description

Olomoucine is a purine that acts as a competitive inhibitor of a variety of cell cycle regulating proteins with high specificity, which leads to the blockage of some cell cycle steps. The compound inhibits: Cdc2/cyclin B, Cdk2/cyclin A and Cdk2/cyclin E kinases, the brain Cdk5/p35 kinase and the ERK1/MAP-kinase. Olomoucine does not significantly inhibit Cdk4/cyclin D1 and Cdk6/cyclin D3 kinases. The compound can induce cell arrest at G1/S and the G2/M, due to its effect on Ckd2 and Cdcd2. Olomoucine also behaves as a competitive inhibitor for ATP and as a non-competitive inhibitor for histone H1 in terms of being Cdk substrates.


Suppliers

Amadis Chemical Company Limited
ACCL3101550
+
Santa Cruz Biotechnology, Inc.
3509
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CAS equal suppliers

Olomoucine, 98%, high purity
Acros Organics BVBA
AOB15966384
2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine
Leap Chem Co., Ltd
LC693020790
2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine
Finipharma Ltd
F539010780

Prices & Availability




Data is processed


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Properties for Olomoucine

Molecular Weight:
298.34 g·mol−1
Density:
1.36
Melting point:
120-130 °C
Boiling point:
579.58° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (32 mg/ml), ethanol (7 mg/ml), water (0.5 mg/ml), DMF (30 mg/ml), and 1:1 DMF:PBS(pH 7.2) (~0.5 mg/ml).
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Safety & Transport Information

Safety Codes:
S24/25 - Avoid contact with skin and eyes
Storage temperature :
-20°C
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Alternative Distributors of [Olomoucine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

SYNCHEM OHG | BOC Sciences

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Downloads

Mol File:
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MSDS:
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