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Oligomycin A

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Formula: C45H74O11
CAS: 579-13-5
search Element: oligomycin
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Identification

Structural Formula
Oligomycin A
CAS:
579-13-5
EINECS:
209-437-3
Molecular Formula:
C45H74O11
MDL:
MFCD00065705
SMILES:
CCC1CCC2[C@@H](C([C@H](C3(O2)CC[C@H](C(O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@@H]([C@H]([C@@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
Synonym:
oligomycin complex ; aoligomyci ; oligomycin a fromstreptomyces diastatochromogenes ; (1r,4e,5's,6s,6's,7r,8s,10r,11r,12s,14r,15s,16r,18e,20e,22r,25s,27r,28s,29r)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2r)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3h,9h,13h-spiro[2,26-dioxabicyclo[23.3.1]nonaco ; oligomycin a mch 32 ; oligomycin, streptomyces diastatochromogenes ; mch 32 ; oligomycin a ; oligomycin a, >=98% ; oligomycin a, streptomyces diastatochromogenes


Description

Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.


Suppliers

Aea.ltd
A168336
+
Shanghai Chong Da Prostaglandin Fine Chemicals Co., Ltd.
SCDPFC13449408
+
Chemlyte Solutions
CS4321296
+
CSNpharm, Inc.
CSN15998
Iris Biotech GmbH
LS-1046
+
BOC Sciences
BS288864
+
Leap Chem Co., Ltd
LC4321296
+
Santa Cruz Biotechnology, Inc.
201551
Dayang Chem (Hangzhou) Co.,Ltd.
DC7442976
+
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Prices & Availability




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Properties for Oligomycin A

Molecular Weight:
791.06 g·mol−1
Density:
1.14
Melting point:
150-151°C
Boiling point:
886.3° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (300 mg/ml), ethanol (200 mg/ml), acetone (800 mg/ml), glacial acetic acid (37.5 g/100ml) at 25° C, water (2 mg/100ml) at 25° C, ether (28 g/100ml) at 25° C, and benzene (6 g/100ml) at 25° C.
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Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R22 - Harmful if swallowed
R68/20/21/22 - Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if swallowed
Safety Codes:
S36/37 - Wear suitable protective clothing and gloves
Hazard Classes:
6.1(b)
Hazard Symbols:
Xn, T
Hazard symbol T Hazard symbol Xn
Storage temperature :
-20°C
RID/ADR certification :
2811
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Alternative Distributors of [Oligomycin A]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Fermentek Ltd. | D&P Global Chemical Co., Ltd

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