5(S),14(R)-Lipoxin B4 | CAS 98049-69-5

Element: lipoxin

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Identification

5(S),14(R)-Lipoxin B4

CAS:

98049-69-5

EINECS:

Molecular Formula:

C₂₀H₃₂O₅

MDL:

MFCD00870250

SMILES:

CCCCC[C@@H]([C@@H](/C=C/C=C/C=CC=C[C@H](CCCC(=O)O)O)O)O

Synonym:

(5s,14r,15s)-5,14,15-trihydroxy-(6e,8z,10e,12e)-eicosatetraenoic acid ; lxb4 ; 5(s), 14(r), 15(s)-trihydroxyeicosa-6e,8z,10e,12e-tetraenoic acid ; (5s,6e,8z,10e,12e,14r,15s)-5,14,15-trihydroxy-6,8,10,12-icosatetraenoic acid ; 5(s),14(r)-lipoxin b4 ; (5s,6e,8z,10e,12e,14r,15s)-5,14,15-trihydroxyicosa-6,8,10,12-tetraenoic acid ; lipoxin b4

Description

A positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. It is apart of a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC₅₀ value of ~3 X 10-10 M.

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Santa Cruz Biotechnology, Inc.

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Lipoxin B4

Dayang Chem (Hangzhou) Co.,Ltd.

DC6202480

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Properties for 5(S),14(R)-Lipoxin B4

Molecular Weight:

352.47 g·mol−1

Boiling point:

78° C

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

F, Xi