7-Hydroxy-DPAT·HBr | CAS 74938-11-7

Element: hydroxy middot dpat

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C-S » Chemicals » hydroxy-dpat-hbr-PX67023

Identification

7-Hydroxy-DPAT·HBr

CAS:

74938-11-7

EINECS:

Molecular Formula:

C₁₆H₂₅ N O

MDL:

MFCD00153809

SMILES:

CCCN(CCC)C1CCC2=C(C1)C=C(C=C2)O

Synonym:

2-naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro- ; 7-hydroxy-dapt ; r(+)-7-oh-dpat ; (?Ã )-7-oh-dpat ; dp-7-at ; 7-oh-dpat hbr ; r(+)-7-oh-dpat-hbr ; 7-hydroxy-dpat hydrobromide ; 7-oh-dpat ; 7-hydroxy-dpat hbr ; 7-hydroxy-n,n-dipropyl-2-aminotetralin ; n,n-dipropyl-7-hydroxy-2-aminotetralin ; 2-(di-n-propylamino)-7-hydroxytetralin ; [+/-]-7-oh-dpat hydrobromide ; (+/-)-7-oh-dpat hydrobromide ; 7-hydroxy-2-(di-n-propylamino)tetralin

Description

7-Hydroxy-DPAT·HBr is a selective D3DR (dopamine receptor) agonist that is primarily found in neurons of the brain. Upon activation by 7-Hydroxy-DPAT·HBr, D3DR's exhibit a decrease in the release of dopamine from neurons and activate phospholipase D via formation of a complex with RhoA. In addition, studies suggest that 7-Hydroxy-DPAT·HBr induces the suppression of cAMP in hamster ovary cells. Since the D3DR is part of the D2DR subfamily, which includes the D2DR, D3DR, and D4DR receptors, ligands such as 7-Hydroxy-DPAT·HBr can also bind to D2DR at a higher concentration. 7-Hydroxy-DPAT·HBr is an activator of D2DR.