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(S)-HDAC-42

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Formula: C18H20N2O3
CAS: 935881-37-1
search Element: hdac
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Identification

Structural Formula
(S)-HDAC-42
CAS:
935881-37-1
EINECS:
Molecular Formula:
C18H20N2O3
MDL:
MFCD17676151
SMILES:
CC(C)[C@@H](C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO
Synonym:
(S)-HDAC-42


Description

(S)-HDAC-42 is a potent inhibitor of HDAC (IC50 = 16 nM in vitro). (S)-HDAC-42 decreases the viability of prostate cancer cell lines (IC50 = 0.40 μM), increasing the expression of p21 and the acetylation of histone H3 while decreasing the phosphorylation of Akt and the expression of Bcl-XL. (S)-HDAC-42 also strongly suppresses the growth of PC-3 tumor xenografts, reducing levels of phospho-Akt and Bcl-XL protein in tumors.


Suppliers

Santa Cruz Biotechnology, Inc.
296364
Dayang Chem (Hangzhou) Co.,Ltd.
DC6822728
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Prices & Availability




Data is processed


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Properties for (S)-HDAC-42

Molecular Weight:
312.4 g·mol−1
Density:
~1.22 g/cm3 (Predicted)
Solubility:
Soluble in 1:1 DMSO:PBS (pH 7.2) (~0.5 mg/ml), ethanol (~20 mg/ml), DMF (~20 mg/ml), DMSO (~20 mg/ml), and water (<1 mg/ml) at 25 °C.
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Safety & Transport Information

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Alternative Distributors of [(S)-HDAC-42]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ShangHai Biochempartner Co., Ltd.

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