HDAC6 Inhibitor

HDAC6 Inhibitor is a selective and potent inhibitor of HDAC6 (IC₅₀ = 0.002 nM, as compared with HDAC1 (IC₅₀ = 271 nM), HDAC2 (IC₅₀ = 252 nM), HDAC3 (IC₅₀ = 0.42 nM), HDAC8 (IC₅₀ = 6851 nM), and HDAC10 (IC₅₀ = 90.7 nM). HDAC6 Inhibitor also prevents the growth of several pancreatic cancer cell lines (IC₅₀ = 0.1-1 μM). HDAC6 Inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroamic acid.