GGTI-286 | CAS 171744-11-9 | Chemical-Suppliers

Element: ggti

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C-S » Chemicals » ggti-PX67220

Identification

GGTI-286

CAS:

171744-11-9

EINECS:

Molecular Formula:

C₂₃H₃₁ N₃ O₃ S

MDL:

SMILES:

CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2

Synonym:

L-Leucine,N-[[5-[(2-amino-3-mercaptopropyl)amino][1,1'-biphenyl]-2-yl]carbonyl]-, methylester, (R)- ; GGTI 286 ; L-Leucine,N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-,methyl ester

Description

GGTI-286 is a potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 is about 25-fold more potent than FTI-277 in inhibiting the processing of the geranylgeranylated protein Rap1A. GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells. It also selectively antagonizes oncogenic K-Ras4B.