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EGFR Inhibitor

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Formula: C21H18F3N5O
CAS: 879127-07-8
search Element: inhibitor egfr
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Identification

Structural Formula
EGFR Inhibitor
CAS:
879127-07-8
EINECS:
Molecular Formula:
C21H18F3N5O
MDL:
SMILES:
C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F
Synonym:
Cyclopropanecarboxamide, N-[3-[[6-[[3-(trifluoromethyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-


Description

EGFR Inhibitor is a cell permeable compound that is a highly selective inhibitor of EGFR (epidermal growth factor receptor). Inhibition of EGFR has been shown to induce apoptosis. Mechanistic studies have shown that EGFR inhibition takes place via downregulation of antiapoptotic protein survivin expression. Downregulation of Survivin has been observed to take place following inhibition of the PI3K-AKT signaling pathway. Additional experiments report that EGFR inhibitors also induce upregulation of proapoptotic protein BIM.


Suppliers

Amadis Chemical Company Limited
ACCL8684340
+
Santa Cruz Biotechnology, Inc.
203934
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Prices & Availability




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Properties for EGFR Inhibitor

Molecular Weight:
413.4 g·mol−1
Solubility:
Soluble in DMSO (50 mg/ml), and ethanol (25 mg/ml).
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Safety & Transport Information

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Alternative Distributors of [EGFR Inhibitor]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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