δ12-PGJ2 (δ12-Prostaglandin J2) | CAS 87893-54-7

Element: prostaglandin delta delta pgj2

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C-S » Chemicals » delta-pgj-delta-prostaglandin-PX70585

Identification

δ12-PGJ2 (δ12-Prostaglandin J2)

CAS:

87893-54-7

EINECS:

Molecular Formula:

C₂₀H₃₀O₄

MDL:

SMILES:

CCCCCC(CC=C1C(C=CC1=O)CC=CCCCC(=O)O)O

Synonym:

delta12-prostaglandin j2 ; (5z,12e,15s)-11-oxo-15-hydroxyprosta-5,9,12-triene-1-oic acid ; c05958 ; Î”12-pgj2 ; 11-oxo-15s-hydroxy-prosta-5z,9,12e-trien-1-oic acid ; Î”12-pgj2 (Î”12-prostaglandin j2) ; 12-prostaglandin j2 ; delta12-pgj2 ; Î”12-prostaglandin j2 lipid maps ms standard ; (5z,12e,15s)-15-hydroxy-11-oxoprosta-5,9,12-trien-1-oic acid

Description

δ12-PGJ2 (δ12-Prostaglandin J2) is a decomposition product of PGD2 that has shown potent antiviral and anit-proliferative activity. This compound has also been shown to induce apoptosis, and to inhibit phosphoinositide turnover. Conjugation with glutathione is thought to enhance the cytotoxicity of δ12-PGJ2. Similar to other prostaglandins, it is often difficult to distinguish between biological activities derived directly from ‘parent' molecules and those derived from metabolites thereof.