Cytochalasin A

Cytochalasin A is used in actin polymerization studies. Cytochalasin A is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. The class of Cytochalasin fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin A is the oxidized analog of cytochalastin B. As opposed to other Cytochalasins, Cytochalasin A and cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin A is sulfhydryl-reactive, and was shown to inhibit growth and sugar uptake in a Saccharomyces strain. Inhibits HIV-1 protease.
Other Cytochalasins available: Cytochalasin C (sc-202118); Cytochalasin D (sc-201442); Cytochalasin E, Aspergillus clavatus (sc-202561); Cytochalasin H (sc-202119); Cytochalasin J (sc-202120)