Cyclopamine | CAS 4449-51-8 | Chemical-Suppliers

Element: cyclopamine

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C-S » Chemicals » cyclopamine-PX76667

Identification

Cyclopamine

CAS:

4449-51-8

EINECS:

Molecular Formula:

C₂₇H₄₁NO₂

MDL:

MFCD01735266

SMILES:

C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1

Synonym:

11-deoxo-jervin ; cyclopamine(rg) ; cyclopamine, >=98% ; 17,23β-epoxyveratraman-3β-ol ; cyclopamine ; 17β,23β-epoxyveratraman-3β-ol ; 11-deoxojervine ; alkaloidv ; cyclopamine (11-deoxojervine) ; 11-deoxyjervine

Description

Cyclopamine is a teratogenic Smo inhibitor famous for inducing cyclopia in developing mammalian fetuses. Cyclopia arises from improper differentiation in the fetus, a process heavily regulated by the Hedgehog (Hh) signaling pathway. The proteins Smo and patched mediate cellular response to the Hedgehog protein signal, and aberrant behavior of these proteins can lead to oncogenic states. While cyclopia and fetal failure are the notorious effects of cyclopamine on development, the compound has also been used to suppress and reverse the effects of oncogenic mutations in Smo and patched.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI7593036

Aea.ltd

A77154

Chemlyte Solutions

CS198594

Autech Industry Co.,Limited

AIC2971188

Ambeed, Inc.

A148971

Indofine Chemical Co, Inc.

08-1995

CSNpharm, Inc.

CSN10720

AK Scientific, Inc.

AS209627

Xingrui Industry Co., Limited

XIL3191276

BOC Sciences

BS132396

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

200929

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

Cyclopamine, 99+%

Alfa (A Johnson Matthey Company)

A5441632

Cyclopamine (11-Deoxyjervine)

United States Biological

C8845

Prices & Availability

Data is processed

Properties for Cyclopamine

Molecular Weight:

411.62 g·mol−1

Density:

1.1 g/cm³ (Predicted)

Melting point:

236-238 °C

Boiling point:

550.79° C at 760 mmHg

Solubility:

DMSO: soluble

Safety & Transport Information

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes

Hazard Symbols:

Storage temperature :

2-8°C

Alternative Distributors of [Cyclopamine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified