8-CPT-cAMP | CAS 93882-12-3 | Chemical-Suppliers

Element: camp

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C-S » Chemicals » cpt-camp-PX71000

Identification

8-CPT-cAMP

CAS:

93882-12-3

EINECS:

299-413-9

Molecular Formula:

C₁₆H₁₄ClN₅NaO₆PS

MDL:

MFCD00057683

SMILES:

C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=NC=N4)N)N=C3SC5=CC=C(C=C5)Cl)O)OP(=O)(O1)[O-].[Na+]

Synonym:

camp, 8-pcpt-, na ; 8-cpt-camp, na ; adenosine,8-[(4-chlorophenyl)thio]-, cyclic 3',5'-(hydrogen phosphate), monosodium salt(9ci) ; 8-cpt-cyclic amp (sodium salt) ; 8-pcpt-camp na ; sodium 6-[6-amino-8-(4-chlorophenyl)sulfanylpurin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol ; sodium (4ar,6r,7r,7as)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9h-purin-9-yl}-7-hydroxytetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide ; 8-(4-chlorophenylthio)adenosine 3':5'-cy clic monop ; 8-cpt-camp ; 8-cpt-camp sodium salt ; 8-(4-chlorophenylthio)-camp sodium ; pcpt-camp ; 8-(4-chlorophenylthio)-adenosine 3':5'-cyclic monophosphate sodium salt ; 8-[(4-chlorophenyl)thio]adenosine 3',5'-phosphoric acid sodium salt

Description

8-CPT-cAMP is an efficient activator of cyclic-GMP-dependent protein kinase (cGK) and cAMP-PK (PKA). Additionally, 8-CPT-cAMP is a robust inhibitor of cyclic GMP-specific phosphodiesterase (PDE) (IC₅₀= 0.9 μM). cGMP-inhibited phosphodiesterase and Ca2⁺/calmodulin-dependent phosphodiesterase have been reported to hydrolyze 8-CPT-cAMP. 8-CPT-cAMP has been used in studies to analyze the signal-transduction pathways initiated by cAMP-PK and cGMP-PK. Research indicates that 8-CPT-cAMP can inhibit thrombin-induced phosphorylation mediated by protein kinase C and myosin light chain kinase.