Compound 401 | CAS 168425-64-7 | Chemical-Suppliers

Element: compound

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » compound-PX63314

Identification

Compound 401

CAS:

168425-64-7

EINECS:

Molecular Formula:

C₁₆H₁₅N₃O₂

MDL:

MFCD10568147

SMILES:

C1COCCN1C2=CC(=O)[N+]3=C(N2)C4=CC=CC=C4C=C3

Synonym:

4h-pyrimido[2,1-a]isoquinolin-4-one, 2-(4-morpholinyl)- ; compound 401, >=98% ; 2-morpholino-4h-pyrimido[2,1-a]isoquinolin-4-one ; 2-(4-morpholinyl)-4h-pyrimido[2,1-a]isoquinolin-4-one ; 2-(morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one

Description

Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC₅₀ = 280 nM) with ~19-fold selectivity over mTOR (FRAP) (IC₅₀ = 5.3 μM). Compound 401 exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Compound 401 has been shown to induce apoptosis and inhibit FRAP-dependent growth in TSC1-/- murine embryo fibroblasts.

Suppliers

Aea.ltd

A84168

CSNpharm, Inc.

CSN17373

Santa Cruz Biotechnology, Inc.

202552

Get Quick Quote

CAS equal suppliers

2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

TCI Chemicals (India) Pvt. Ltd.

M2537

2-(Morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one

Leap Chem Co., Ltd

LC630018900

Prices & Availability

Data is processed

Properties for Compound 401

Molecular Weight:

281.314 g·mol−1

Density:

1.36 ±0.1 g/cm3 (20 °C 760 Torr)

Melting point:

184-186°C (ethanol )

Boiling point:

456.92° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (5 mg/ml), and ethanol (5 mM).

Safety & Transport Information

Storage temperature :

Store at RT

Alternative Distributors of [Compound 401]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ShangHai Biochempartner Co., Ltd. | Sino Rarechem Labs Co. Ltd. | D&P Global Chemical Co., Ltd