Clozapine | CAS 5786-21-0 | Chemical-Suppliers

Element: clozapine

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Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » clozapine-PX68514

Identification

Clozapine

CAS:

5786-21-0

EINECS:

227-313-7

Molecular Formula:

C₁₈H₁₉ClN₄

MDL:

MFCD00153785

SMILES:

CN1CCN(CC1)C1=NC2=CC(Cl)=CC=C2NC2=C1C=CC=C2

Synonym:

iprox ; w-801 ; liponex ; leponex ; lepotex ; hf-1854 ; ozapine ; fazaclo ; clozapin ; clorazil

Description

Clozapine preferentially inhibits D4DR (D₄-dopamine receptor) and SR-2 and acts as a weak D₁ and D₂ antagonist. Clozapine is also reported to inhibit SR-2A, SR-2C, SR-3, SR-6 and SR-7. Two major metabolites of Clozapine are reported to be N-Desmethyl Clozapine (labeled compound) and Clozapine N-oxide. Additionally, reversed-phase HPLC has been reported as a method of identification of Clozapine and its two major metabolites. In studies investigating the induction of neutrophil apoptosis in rabbits by oxidation of Clozapine into reactive nitrenium ion, it was noted that Clozapine increased the rate of neutrophil release from bone marrow while also affecting the neutrophil half-life in the peripheral blood stream of rabbits.Clozapine is also available as a labeled analog. Clozapine is an inhibitor of D2DR.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

Shandong Minglang Chemical Co., Ltd

SMC3151260

H&Z Industry Co.,Ltd

HIC180720

Krada CPS Industry S.L

KCIS198990

Nantong Xindao Biotech Ltd

NXB234936

Chemlyte Solutions

CS162486

Autech Industry Co.,Limited

AIC243972

Aozeal Certified Standards (AOCS), Inc.

C0048.00

Arevipharma GmbH

A144288

BoomKing Industrial Co.,Limited

BIC2791116

Xiamen Equation Chemical Co.,Ltd

XECC2881440

Aecochem Corp.

AC126378

Sigma-Aldrich International GmbH

SI288864

scienTEST - bioKEMIX GmbH

S-B225900

Carbone Scientific Co., Ltd.

CS252756

AK Scientific, Inc.

AS171513

Santa Cruz Biotechnology, Inc.

200402

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Prices & Availability

Data is processed

Properties for Clozapine

Molecular Weight:

326.82 g·mol−1

Density:

~1.3 g/cm³ (Predicted)

Melting point:

182-185°C

Boiling point:

489.16° C at 760 mmHg (Predicted)

Solubility:

ethanol: 1 mg/mL

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R22 - Harmful if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
R63 - Possible risk of harm to the unborn child
R68 - Possible risk of irreversible effects

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S7 - Keep container tightly closed

Hazard Classes:

6.1(b)

Hazard Symbols:

Xn, Xi, T, F
Hazard symbol T

Storage temperature :

Store at RT

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Clozapine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified