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N-Desmethylclozapine

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Formula: C17H17 Cl N4
CAS: 6104-71-8
search Element: desmethylclozapine
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Identification

Structural Formula
N-Desmethylclozapine
CAS:
6104-71-8
EINECS:
Molecular Formula:
C17H17 Cl N4
MDL:
MFCD00210189
SMILES:
C1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
Synonym:
n-demethylclozapine ; clozapine ep impurity c ; desmethylclozapine ; n-desmethylclozapine solution ; norclozapine ; demethylclozapine ; 8-chloro-11-(1-piperazinyl)-5h-dibenzo[b,e][1,4]diazepine ; 5h-dibenzo[b,e][1,4]diazepine,8-chloro-11-(1-piperazinyl)- ; n-desmethyl clozapine-d8 hydrochloride ; normethylclozapine ; 8-chloro-11-1[1-piperazinyl)-5h-dibenzo[b,e][1,4]diazepine ; 8-chloro-11-piperazinyl-5h-dibenzo[b,e][1,4]diazepine ; n-desmethylclozapine ; acp 104


Description

N-Desmethylclozapine (NDMC), a major metabolite of clozapine, has been found to act as an antagonist of phosphoinositide hydrolysis stimulated by serotonin receptors. NDMC has been shown to be a potent antagonist of SR-2C (aka: 5HT2C), and has been reported to act as a moderate agonist of the rat native and human recombinant mAChR M1(CHRM1). N-Desmethylclozapine is an activator of D2DR and D3DR.


Suppliers

Chemlyte Solutions
CS3601080
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Finetech Industry Limited
FIL5002000
+
Amadis Chemical Company Limited
ACCL6203100
+
Santa Cruz Biotechnology, Inc.
201113
Dayang Chem (Hangzhou) Co.,Ltd.
DC6202480
+
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Prices & Availability




Data is processed


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Properties for N-Desmethylclozapine

Molecular Weight:
312.8 g·mol−1
Melting point:
120-125°C
Solubility:
Soluble in ethanol (25 mg/ml), DMSO (>44 mg/ml), chloroform, and methanol.
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Safety & Transport Information

Risk Codes:
R11 - Highly flammable
R20/22 - Harmful by inhalation and if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Codes:
S16 - Keep away from sources of ignition - No smoking
S22 - Do not breathe dust
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S7 - Keep container tightly closed
Hazard Classes:
6.1(b)
Hazard Symbols:
Xn, T, F
Hazard symbol T Hazard symbol F Hazard symbol Xn
Storage temperature :
Store at RT
RID/ADR certification :
3249
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Alternative Distributors of [N-Desmethylclozapine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Abcam Biochemicals plc (formaly Ascent Scientific Ltd.) | BOC Sciences

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Downloads

Mol File:
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MSDS:
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