Ceramide C6 | CAS 124753-97-5 | Chemical-Suppliers

Element: ceramide

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » ceramide-PX70718

Identification

Ceramide C6

CAS:

124753-97-5

EINECS:

Molecular Formula:

C₂₄H₄₇NO₃

MDL:

MFCD00870174

SMILES:

CCCCCCCCCCCCC/C=C/[C@@H]([C@@H](CO)NC(=O)CCCCC)O

Synonym:

c6-d-erythro-ceramide ; n-hexanoyl-d-sphingosine ; 06:0 ceramide ; n-hexanoylsphingosine ; n-hexanoy-d-sphingosine ; ceramide c6 ; c6 ceramide ; caproyl ceramide ; n-caproyl-d-sphingosine ; c8 sphingoid base

Description

Ceramide C6 is a cell-permeable, non-physiologic analog displaying biological activity, including stimulation of protein phosphatase 2A (PP2) and activation of MAP kinase (ERK). Molt-4 leukemia cells are arrested at the G₀/G₁ phase (10μM) and apoptosis occurs at concentrations greater than 15μM. Ceramide C6 has been observed to enhance expression of COX-2 in rat granulosa cells and stimulate growth of aortic smooth muscle cells in bovines. Further observations of chemical functions include apoptosis of HL-60 cells, suppression of insulin-induced Tyr phosphorylation, inhibition of neurite growth, and inhibition of glycoprotein traffic via the secretory pathway.