Rp-8-Br-cAMPS | CAS 129735-00-8 | Chemical-Suppliers

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C-S » Chemicals » camps-PX72921

Identification

Rp-8-Br-cAMPS

CAS:

129735-00-8

EINECS:

Molecular Formula:

C₁₀H₁₁ Br N₅ O₅ P S

MDL:

MFCD04037241

SMILES:

OC1C2OP(=S)([O-])OC[C@H]2O[C@H]1n1c(Br)nc2c1ncnc2N.[Na+]

Synonym:

adenosine 3',5'-cyclic monophosphorothioate, 8-bromo-, rp-isomer, sodium salt ; 4h-furo[3,2-d]-1,3,2-dioxaphosphorin,adenosine deriv. ; 8-bromoadenosine-3'',5''-cyclic monophosphothioate rp isomer ; adenosine, 8-bromo-,cyclic 3',5'-[hydrogen [p(r)]-phosphorothioate] (9ci) ; adenosine,8-bromo-, cyclic 3',5'-(hydrogen phosphorothioate), (r)- ; rp-8-br-camps ; 8-bromoadenosine 3',5'-cyclic monophosphothioate, rp-isomer sodium salt ; 8-br-camps na, rp-isomer ; 8-bromoadenosine-3',5'-cyclic monophosphorothioate, rp-isomer sodium salt ; 8-bromoadenosine-3',5'-cyclic monophosphorothioate sodium salt, rpisomer ; 8-bromoadenosine-3',5'-cyclic * monophosphorothioat ; rp-8-br-camps sodium salt ; rp-8-br-camps, na

Description

Rp-8-Br-cAMPS is a lipophilic analog of Rp-cAMPS, demonstrating competitve preferential inhibition of PKA (PKC-&alpha). Rp-8-Br-cAMPS is believed to function by occupying cAMP binding sites thus preventing dissociation and activation of the kinase holoenzyme. Rp-8-Br-cAMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. This compound is significantly more lipophilic and membrane permeant compared to Rp-cAMPS or 8-Br-cAMP.