(S)-(-)-Blebbistatin | CAS 856925-71-8

Element: blebbistatin

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C-S » Chemicals » blebbistatin-PX65865

Identification

(S)-(-)-Blebbistatin

CAS:

856925-71-8

EINECS:

Molecular Formula:

C₁₈H₁₆ N₂ O₂

MDL:

MFCD08460907

SMILES:

CC1=CC2=C(C=C1)N=C3[C@](C2=O)(CCN3C4=CC=CC=C4)O

Synonym:

3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4h-pyrrolo[2,3-b]quinolin-4-one 1,2,3,3atetrahydro3ahydroxy6methyl1phenyl4hpyrrolo[2,3b]quinolin4one ; (s)-(-)-blebbistatin ; 3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4h-pyrrolo[2,3-b]quinolin-4-one (-)-blebbistatin ; 4h-pyrrolo[2,3-b]quinolin-4-one,1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3as)- ; (-)-blebbistatin ; (+/-)-blebbistatin ; 4h-pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3as)-

Description

(S)-(-)-Blebbistatin is a selective inhibitor of myosin II (MYH2). It also inhibits contraction of the cleavage furrow without disrupting of mitosis or the contractile ring assembly. (S)-(-)-Blebbistatin exhibits rapid and reversible blocking of cell blebbing, as well as disruption of directed cell migration and of cytokinesis in vertebrate cells.

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Prices & Availability

Data is processed

Properties for (S)-(-)-Blebbistatin

Molecular Weight:

292.336 g·mol−1

Density:

~1.3 g/cm³ (Predicted)

Melting point:

210-212 °C

Boiling point:

~507.3° C at 760 mmHg (Predicted)

Solubility:

Soluble in methanol (1.5 mg/ml), DMSO (100 mM), Dichloromethane, ethyl acetate, chloroform, methylene chloride, DMF (~12.5 mg/ml), 1:1 solution of DMF:PBS (pH 7.2) (~0.5 mg/ml), and water (0.5 mg/ml at 25° C).

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves

Hazard Symbols: