Bisindolylmaleimide I, HCl | CAS 176504-36-2

Element: bisindolylmaleimide

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C-S » Chemicals » bisindolylmaleimide-hcl-PX78910

Identification

Bisindolylmaleimide I, HCl

CAS:

176504-36-2

EINECS:

Molecular Formula:

C₂₅H₂₄ N₄ O₂ . Cl H

MDL:

MFCD00236429

SMILES:

CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54.Cl

Synonym:

bisindolylmaleimide i . hydrochloride [gf-109203k ; 1h-pyrrole-2,5-dione,3-[1-[3-(dimethylamino)propyl]-1h-indol-3-yl]-4-(1h-indol-3-yl)-,monohydrochloride (9ci) ; 3-[1-[3-(dimethylamino)propyl]-1h-indol-3-yl]-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione monohydrochloride ; bim 1 hydrochloride ; 1h-pyrrole-2,5-dione,3-[1-[3-(dimethylamino)propyl]-1h-indol-3-yl]-4-(1h-indol-3-yl)-, hydrochloride(1:1) ; 3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride ; bisindolylmaleimide i( hydrochloride salt)

Description

Bisindolylmaleimide I, HCl is a water soluble form of Bisindolylmaleimide I; a staurosporine inspired molecule, which has been shown to display equally potent inhibition, but with vastly superior selectivity for all of the known isoforms of PKC (IC₅₀ = 8-20 nM). Inhibition is competitive with respect to ATP, which suggests that Bisindolylmaleimide I occupies the ATP binding domain of the PKC isoforms. This compound has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. Shown to inhibit PKC (protein kinase C) within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases. Bisindolylmaleimide I, HCl is an inhibitor of PKC α, PKC β, PKCδ, PKC ε and PKC γ.