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Bisindolylmaleimide I (GF 109203X)

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Formula: C25H24N4O2
CAS: 133052-90-1

Identification

Structural Formula
Bisindolylmaleimide I (GF 109203X)
CAS:
133052-90-1
EINECS:
Molecular Formula:
C25H24N4O2
MDL:
MFCD00236428
SMILES:
CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
Synonym:
gf 109203x ; go 6850 ; go 6850 hcl ; g 6850] ; gf-109203x hcl ; bim 1 ; bisindolylmaleimide ; bisindoylmaleimide ; bisindolylmaleinimide ; bisindolylmaleimide i


Description

Bisindolylmaleimide I (GF 109203X) is a staurosporine inspired molecule, which has been shown to display equally potent inhibition, but with vastly superior selectivity, for all of the known isoforms of PKC (IC50 = 8-20 nM). Inhibition is competitive with respect to ATP, which suggests that Bisindolylmaleimide I occupies the ATP binding domain of the PKC isoforms. Bisindolylmaleimide I (GF 109203X) has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It inhibits PKC within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases, as well as GSK-3. See sc-24004 for water soluble form of Bisindolylmaleimide I. Bisindolylmaleimide I (GF 109203X) is an inhibitor of PHK/CaM, PKC α, PKC β, PKC δ, PKC ε, PKC γ and SR/HTR3.


Suppliers

Santa Cruz Biotechnology, Inc.
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Prices & Availability




Data is processed


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Properties for Bisindolylmaleimide I (GF 109203X)

Molecular Weight:
412.48 g·mol−1
Density:
~1.31 g/cm3 (Predicted)
Melting point:
280 °C (decomposition)
Boiling point:
~685.64 °C at 760 mmHg (Predicted)
Solubility:
DMSO: ~1 mg/mlsoluble
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R40 - Limited evidence of a carcinogenic effect
Safety Codes:
S36/37 - Wear suitable protective clothing and gloves
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [Bisindolylmaleimide I (GF 109203X)]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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