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Aurora Kinase/Cdk Inhibitor

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Formula: C15H12F2N6O3S
CAS: 443797-96-4
search Element: inhibitor aurora kinase
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Identification

Structural Formula
Aurora Kinase/Cdk Inhibitor
CAS:
443797-96-4
EINECS:
Molecular Formula:
C15H12F2N6O3S
MDL:
MFCD11100270
SMILES:
CC#N.Nc1nc(Nc2ccc(cc2)S(=O)(=O)N)nn1C(=O)c1c(F)cccc1F
Synonym:


Description

Aurora Kinase/Cdk inhibitor (JNJ-7706621) is a cell-permeable triazolylsulfonamido compound that acts as a reversible, ATP-competitive kinase inhibitor with selectivity towards ARKs (IC50 = 11 and 15 nM for ARK-1 (Aurora-A) and ARK-2 (Aurora-B), respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdc2 (Cdk1)/B, Cdk2/A, and Cdk2/E, respectively). Aurora Kinase/Cdk Inhibitor displays antitumor properties (IC50 in the range of 112-514 nM against various human cancer cell lines).


Suppliers

Alfa (A Johnson Matthey Company)
A345610368
Santa Cruz Biotechnology, Inc.
203829
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CAS equal suppliers

JNJ7706621
ShangHai Biochempartner Co., Ltd.
BCP01836
JNJ7706621
Hangzhou J&H Chemical Co., Ltd.
HJC3101240
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Capot Chemical Co., Ltd.
22455
JNJ7706621
Excenen Pharmatech Co., Ltd.
EX-A1979
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Ambeed, Inc.
A262123
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CSNpharm, Inc.
CSN12858
JNJ-7706621
Aea.ltd
A77154
4-((5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC115056
4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide
Chemieliva Pharmaceutical Co., Ltd.
CP2870086100
4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide
Leap Chem Co., Ltd
LC1476044280
4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide
Hefei Hirisun Pharmatech Co., Ltd
HR130515
4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide
Finipharma Ltd
F1148022960

Prices & Availability




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Properties for Aurora Kinase/Cdk Inhibitor

Molecular Weight:
394.36 g·mol−1
Density:
1.71 g/cm3
Melting point:
149-155 °C
Boiling point:
676.6 °C at 760 mmHg
Flash point:
363 °C
Solubility:
Soluble in DMSO.
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Safety & Transport Information

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Alternative Distributors of [Aurora Kinase/Cdk Inhibitor]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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