Amphotericin B | CAS 1397-89-3 | Chemical-Suppliers

Element: amphotericin

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C-S » Chemicals » amphotericin-PX488895

Identification

Amphotericin B

CAS:

1397-89-3

EINECS:

215-742-2

Molecular Formula:

C₄₇H₇₃NO₁₇

MDL:

MFCD00877763

SMILES:

C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O

Synonym:

lns-amb ; halizon ; fungizone ; ns718 ; abelcet ; fungilin ; ambisome ; amphocin ; amphozone ; abelecet

Description

Amphotericin B, Streptomyces sp. is a polyene antifungal antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. The compounds mechanism of action is to bind to sterols and disrupt the osmotic integrity of the fungal membrane. In addition to Amphotericin B's antifungal activity it has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B, Streptomyces sp. was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D sensitivity in drug resistant HELA cells in vitro.

Suppliers

Shandong SanYoung Industry Co., Ltd

SSI9803920

XD BIOCHEMS Ltd

XB4201260

Nantong Xindao Biotech Ltd

NXB7282912

Chemlyte Solutions

CS5041512

Ambeed, Inc.

A119196

Aozeal Certified Standards (AOCS), Inc.

A0054.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI19327728

Amresco Inc.

A336672

R.J. Chemicals, Inc.

RC5601680

Indofine Chemical Co, Inc.

A0103

X´ian Taicheng Chem Co., Ltd

XTC8123248

Xiamen Equation Chemical Co.,Ltd

XECC8964480

Hangzhou Zhongqi Chem Co., Ltd

HZC8403360

Aecochem Corp.

AC3921176

CSNpharm, Inc.

CSN10299

Hangzhou Lingrui Chemical Co., Ltd.

HLC9803920

Sigma-Aldrich International GmbH

SI8962688

scienTEST - bioKEMIX GmbH

S-B7002800

Finetech Industry Limited

FIL7002800

Carbone Scientific Co., Ltd.

CS7842352

AK Scientific, Inc.

AS5321596

Xingrui Industry Co., Limited

XIL8123248

Leap Chem Co., Ltd

LC5041512

Santa Cruz Biotechnology, Inc.

202462

Dayang Chem (Hangzhou) Co.,Ltd.

DC8683472

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CAS equal suppliers

Amphotericin B, USP

United States Biological

A2220

Amphotericin B, Pharma

Vivimed Labs USA Inc

VLUI13206600

Amphotericin B, Pharma

Zeta Pharmaceuticals Inc.

ZP16504950

Amphotericin b 1397-89-3

Gihi Chemicals Co., Limited

GCL259210368

Amphotericin B trihydrate

Santa Cruz Biotechnology, Inc.

227265

Amphotericin B Solution, 100X

United States Biological

A2230

Amphotericin B injection grade

scienTEST - bioKEMIX GmbH

S-B300012000

Amphotericin B injection grade

Nantong Xindao Biotech Ltd

NXB312012480

Amphotericin B Methyl Ester 90%

Santa Cruz Biotechnology, Inc.

sc-353010

Amphotericin B - Injection grade

Molekula

22793495

Amphotericin B, Streptomyces nodosus

Alfa (A Johnson Matthey Company)

A460813824

Amphotericin B, 250 µg/mL in distilled water, sterile-filtered

Alfa (A Johnson Matthey Company)

A1612848384

Prices & Availability

Data is processed

Properties for Amphotericin B

Molecular Weight:

924.08 g·mol−1

Density:

1.34

Melting point:

>170 °C

Boiling point:

~1140.4° C at 760 mmHg (Predicted)

Solubility:

sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at -20?#x00b0;C. Stable at 37?#x00b0;C for 3 days.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R40 - Limited evidence of a carcinogenic effect

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(b)

Hazard Symbols:

C, Xi, Xn, T
Hazard symbol T

Storage temperature :

2-8°C

RID/ADR certification :

UN 1759 8 / PG 3

Alternative Distributors of [Amphotericin B]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified