Amphotericin B trihydrate | CAS 1397-89-3

Element: amphotericin trihydrate

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C-S » Chemicals » amphotericin-trihydrate-PX61732

Identification

Amphotericin B trihydrate

CAS:

1397-89-3

EINECS:

215-742-2

Molecular Formula:

C₄₇H₇₃NO₁₇

MDL:

MFCD00877763

SMILES:

CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

Synonym:

lns-amb ; halizon ; fungizone ; ns718 ; abelcet ; fungilin ; ambisome ; amphocin ; amphozone ; abelecet

Description

Amphotericin B trihydrate is a polyene antifungal antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. Its mechanism of action is to bind to sterols and disrupt the osmotic integrity of the fungal membrane. In addition to Amphotericin B trihydrate's antifungal activity it has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D sensitivity in drug resistant HELA cells in vitro.

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Prices & Availability

Data is processed

Properties for Amphotericin B trihydrate

Molecular Weight:

924.08 g·mol−1

Density:

1.34

Melting point:

>170 °C

Boiling point:

~1140.4° C at 760 mmHg (Predicted)

Solubility:

sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at -20?#x00b0;C. Stable at 37?#x00b0;C for 3 days.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R40 - Limited evidence of a carcinogenic effect

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(b)

Hazard Symbols:

C, Xi, Xn, T
Hazard symbol T

Storage temperature :

2-8°C

RID/ADR certification :

UN 1759 8 / PG 3

Alternative Distributors of [Amphotericin B trihydrate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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