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N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-trityl-L-lysine

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Formula: C40H38 N2 O4
CAS: 111061-54-2

Identification

Structural Formula
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-trityl-L-lysine
CAS:
111061-54-2
EINECS:
Molecular Formula:
C40H38 N2 O4
MDL:
MFCD00270545
Synonym:
l-lysine,n2-[(9h-fluoren-9-ylmethoxy)carbonyl]-n6-(triphenylmethyl)- ; n2-[(9h-fluoren-9-ylmethoxy)carbonyl]-n6-(triphenylmethyl)-l-lysine ; (s)-2-(((9h-fluoren-9-yl)methoxy)carbonylamino)-6-(tritylamino)hexanoic acid


Description

Building block with side protection orthogonal to Fmoc/tBu strategy. Can be used for side specific derivatization, for example for TFA mediated in situ cyclization, which is taking advantage of intermediate aspartamide formation. Reference: A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage; Koushik Chandra, Tapta Kanchan Roy, Deborah E. Shalev, Abraham Loyter, Chaim Gilon, R. Benny Gerber, and Assaf Friedler; Angew. Chem. Int. Ed. 2014; 53: 9450-9455. DOI: 10.1002/anie.201402789.


Suppliers

Iris Biotech GmbH
FAA1140
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Properties for N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-trityl-L-lysine

Molecular Weight:
610.75 g·mol−1
Melting point:
145°C
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Alternative Distributors of [N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-trityl-L-lysine]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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