Actinomycin D | CAS 50-76-0 | Chemical-Suppliers

Element: actinomycin

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C-S » Chemicals » actinomycin-PX81335

Identification

Actinomycin D

CAS:

50-76-0

EINECS:

200-063-6

Molecular Formula:

C₆₂H₈₆N₁₂O₁₆

MDL:

MFCD00005033

SMILES:

CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

Synonym:

Description

Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. This compound is also an RNA polymerase inhibitor. In studies it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA), and can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.

Suppliers

Aea.ltd

A182364

Shandong SanYoung Industry Co., Ltd

SSI9103640

Chemlyte Solutions

CS4681404

Autech Industry Co.,Limited

AIC7022808

Indofine Chemical Co, Inc.

Bio-011

A.G. Scientific

AS3901170

scienTEST - bioKEMIX GmbH

S-B6502600

Pharmacore Co., Limited

PL5981794

Iris Biotech GmbH

LS-1004

BOC Sciences

BS312936

Amadis Chemical Company Limited

ACCL8064030

Leap Chem Co., Ltd

LC4681404

Santa Cruz Biotechnology, Inc.

200906

Dayang Chem (Hangzhou) Co.,Ltd.

DC8063224

Chemos GmbH & Co. KG

CC5201560

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Prices & Availability

Data is processed

Properties for Actinomycin D

Molecular Weight:

1255.42 g·mol−1

Density:

1.43 g/cm³ (Predicted)

Melting point:

251-253° C

Boiling point:

1386.05° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (>20 mg/ml), 100% ethanol (1 mg/ml), methanol, chloroform, acetonitrile (9.80 - 10.20 mg/ml), and 1,2-Propanediol.

Safety & Transport Information

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Alternative Distributors of [Actinomycin D]

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